The medical recommendations for adult LCH have been published in Orphanet Journal of Rare Diseases.

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Pregnancy

Author(s): Euro Histio Net Work Group for LCH Guidelines for adults (see introduction page), Created: 2012/07/26, last update: 2014/02/09

There are only a few reports about pregnancy and LCH with worsening to no change of clinical symptoms, but even improvement was observed. Deterioration was mainly related to diabetes insipidus. It is unclear if worsening or onset of DI during pregnancy is really caused by LCH. This may also be observed in women not suffering from a histiocytic disorder and is caused by an accelerated degradation of vasopressin through placental enzyme vasopressinase [Ananthakrishnan 2009].

It is unpredictable if and in which way pregnancy may influence the course of LCH. The scant literature suggests there is no adverse impact of LCH on pregnancy or birth, with exception of need for cesarean section in selected cases [DiMaggio/Lippes/Lee 1995; Sharma/Maplethorpe/Wilson 2006]. (Grade C2 *)

* Grades of recommendation see here.

References

[Ananthakrishnan 2009] Ananthakrishnan S: Diabetes insipidus in pregnancy: etiology, evaluation, and management. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2009 May-Jun; 15: 377 [PMID: 19454377]

[DiMaggio/Lippes/Lee 1995] DiMaggio LA, Lippes HA, Lee RV: Histiocytosis X and pregnancy. Obstetrics and gynecology 1995, 85(5 Pt 2): 806 [PMID: 7724119]

[Sharma/Maplethorpe/Wilson 2006] Sharma R, Maplethorpe R, Wilson G: Effect of pregnancy on lung function in adult pulmonary Langerhans cell histiocytosis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2006, 19: 67 [PMID: 16492595]