The medical guidelines for childhood LCH have been published in Pediatric Blood & Cancer  (PBC), Wiley Online Library.

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European Union Clinical Trials Register of the European Medicines Agency

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Follow-up - Required Tests and Frequency

Author(s): Euro Histio Net Work Group for LCH Guidelines (see introduction page), Created: 2011/05/21, last update: 2012/01/23

Tab. 7. Recommendations for follow-up of patients with LCH

Group of Patients

Test

Frequency

All Patients
 

Clinical assessment
 

End of therapy
Every clinc visit

 

Height, Weight, Pubertal status
 
 

End of therapy
Every 6 months until final height is achieved

 

History of thirst, polyuria

Every clinic visit

 

Neurological assessment

Every clinic visit

With involvement of bone (axial skeleton and/or limbs)

Orthopaedic assessment
 

End of therapy
Yearly until completion of pubertal growth

With involvement of ear, mastoid and skull base
 

Audiometry or Audiometry
Evoked Responses in younger children

End of therapy
Before entering school
If symptoms develop

With involvement of oral tissue and jaw

Dental assessment
 

Yearly
 

CNS positive or with involvement of skull base (orbital lesions, DI, anterior pituitary deficiency)

Neuropsychometric assessment
 
 

End of therapy
Every 1 - 2 years
 

 

Cerebral MRI
(details see here)

End of therapy

With involvement of lungs
 
 

Spirometry
 
 

End of therapy
Every 6 months for 2 years
Every year for 10 yerars

With involvement of liver

Sonography

End of therapy

 

Bilirubin, γGT, Alkaline phosphatase

End of therapy