The medical guidelines for childhood LCH have been published in Pediatric Blood & Cancer  (PBC), Wiley Online Library.

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» Expert Histio Net » For Professionals » Guidelines » LCH childhood » Follow-up » Associated Malignancies  · 

Malignancies Associated with Langerhans Cell Histiocytosis

Author(s): Euro Histio Net Work Group for LCH Guidelines (see introduction page), Created: 2011/05/21, last update: 2013/08/28

There is a recognized association between LCH and malignancies [Haupt et al 2005]. The malignancies may precede, occur concurrently or follow the diagnosis of LCH and should be considered at every clinical visit.

Acute leukemia should be considered in patients who develop signs of bone marrow involvement or hepatosplenomegaly. Acute lymphoblastic leukemia and lymphoma more often occur prior to the diagnosis of LCH but may be diagnosed within 5 years after LCH.
Myeloid leukemias usually follow LCH especially in those patients exposed to etoposide, alkylating agents and/or radiotherapy. With the current treatment strategy it is expected that these types of secondary malignancy will hopefully be exceptional.

Solid tumours may precede, occur concurrently or follow the diagnosis of LCH. Most of those that followed LCH developed in a previous radiation field e.g. sarcoma, skin cancer, thyroid cancer.

References

[Haupt et al 2005] Haupt R, Nanduri VR, Calevo MG, Egeler RM: Late effects of Langerhans cell Histiocytosis and the association of LCH with malignancy. Cambridge University Press: Histiocytic Disorders in Children and Adults (ed. by Weitzman S, Egeler RM) 2005 [ISBN: 9780521184168