The medical guidelines for childhood LCH have been published in Pediatric Blood & Cancer  (PBC), Wiley Online Library.

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» Expert Histio Net » For Professionals » Guidelines » LCH childhood » Pretreatment Clinical Evaluation  · 

Pretreatment Clinical Evaluation

Author(s): Euro Histio Net Work Group for LCH Guidelines (see introduction page), Created: 2011/03/09, last update: 2012/01/23

The following patient evaluation is recommended only for patients with definite diagnosis of LCH and for those with presumptive LCH in whom a biopsy is deferred for the reasons mentioned in the chapter Biopsy / Histology. In all other cases we suggest either consulting the referral center of your country or sharing the histological slides with other reference or specialized centers.

Table of Contents

  • Recommended Evaluation in Every Case
    Complete History; Complete Physical Examination; Laboratory and Radiographic Evaluation
  • Specific Clinical Scenarios and Recommended Additional Testing
    History of polyuria or polydipsia; bicytopenia, pancytopenia, or persistent unexplained single cytopenia; liver dysfunction; lung involvement; suspected craniofacial bone lesions including maxilla and mandible; vertebral lesions (even if only suspected); Visual or neurological abnormalities; Suspected other endocrine abnormality; aural discharge or suspected hearing impairment / mastoid involvement; unexplained chronic diarrhea, failure to thrive, or evidence of malabsorption
  • Definition of Organ Involvement
    Possibly involved organs: bone, skin, hematopoietic system, spleen, liver, lung, mucosea, eye, ear, pituitary, CNS, other; risk organs; special sites
  • Head MRI in LCH Patients
    Technique and frequency of MRI surveillance