The medical guidelines for childhood LCH have been published in Pediatric Blood & Cancer  (PBC), Wiley Online Library.

More ...
An­nu­al in­ter­na­tio­nal con­fe­rence of sci­en­tists, pa­tho­lo­gists and cli­ni­ci­ans discussing histiocytoses and their backgrounds. More ...
An International Community of Professionals Dedicated to Research and Treatment More ...
PubMed comprises more than 20 million citations for biomedical literature from MEDLINE, life science journals, and online books. More ...

European Union Clinical Trials Register of the European Medicines Agency

More ...

European Clinical Trials Database of the European Medicines Agency

More ...
Rare diseases in EU
Why do rare diseases need specific EU support? More ...
Euro Histio Net has received funding from the European Union, in the framework of the Public Health Programme. More ...

Diagnostic Criteria

Author(s): Euro Histio Net Work Group for LCH Guidelines (see introduction page), Created: 2011/03/09, last update: 2012/01/23

The diagnosis is clinicopathologic and should only be made in the correct clinical setting to prevent misdiagnosis in the presence of normal reactive Langerhans cells particularly in regional lymph nodes.

The two levels of certainty of LCH diagnosis which are generally agreed upon are shown in the following Table 2.

Tab. 2.

Diagnostic Criteria of LCH




= Based on microscopic examination and at least one of the following immunological staining:

  • Langerin (CD 207) positivity
  • CD1a positivity
  • Presence of Birbeck granules on electronic microscopy

(or compatible)

= Based only on clinico-radiological evidence, without biopsy, as in case of:

  • Typical bone lesion (in a difficult to reach region) with/without diabetes insipidus
  • Pulmonary lesions on CT scan with typical cysts and nodules in a smoker (however, biopsy should be considered in order to reach a more definitive diagnosis)